These are really nice shoes. I've done around 1000 miles in them and enjoy using them. The build quality is great and the plastic/rubber things on the front and heel of the shoe show little to no wear, but the lacquer from the toe of one of the soles has chipped away due to planting my feet at stop lights. The ventilation on the front of the shoe is really effective and I've ended up with cold toes multiple times if temperatures dropped into the 60s, but I imagine this will be excellent when the temperatures pick up. Furthermore, I have not had the shoes heat molded, but I still think they are very comfortable and I've never had any hot spots. The ratcheting strap works really well and allows for a really secure fit without constricting blood flow to your foot. The velcro closures work well as well, and show no signs of fraying. Overall, at $150 these are a steal.
For reference, I have a pair of Mavic shoes that are a size 12 (USA) and the Shimano in 46 (EUR) fit me really well.