In short, this saddle is the proverbial "bomb!" It's awesome.
I bought this saddle from a local bike shop a couple of weeks after it hit the market in the U.S. I've owned three other saddles: a Selle Italia SLX flow, a Specialized Toupe + Expert, and an Antares, which I found terribly uncomfortable after mile 45. After re-checking the "animal" in me, pursuant to Fizik's spine concept, AND measuring my sit bone width properly, I realized I am a "snake," not a "chameleon."
After nearly 1,300 miles, including a Century and a 200K, and just under 70 hrs on the saddle since acquiring the Arione VSX, I can tell you this saddle is, by far, the most comfortable saddle I've ever ridden.