I use this product a lot on day trips and high intensity activities - gives a good kick when headed for a bonk. On longer trips and low intensity activities I prefer to get my calories in more satisfying ways - nuts, energy bars (like probar or cliff). You get more calorie/weight in those. If you do decide to use this product I recommend first buying a six pack of the five oz. flasks. Then reload those with the bigger volume bottle. You can reuse the small flasks for years (at least I have) and they pack easier.
My bottom line opinion is this is really not worth bringing on multi day trips since you can get your calories in more dense and satisfying ways. This is super sugary sweet - not terrible, but certainly not something I salivate over in anticipation! The ideal use for EFS is when you are involved in fairly intense activities (racing, backcountry skiing, climbing), and you need to keep the calories coming in a quick and easily digestible manner. For that purpose EFS is great.
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The hydration sleeve is just one big open pocket the size of the pack so there is no reason other bladders can't be used, as long as they are not too big. The dimensions of the Nathan bladder are about 6" x 15" when laid out flat. Is your 2L Osprey the 70 oz model? That might work, but pay attention to the dimensions (see picture below). When the 2 L Nathan bladder is full it's a pretty tight fit. I use this vest with a couple of bladders: the 2L bladder it comes with and a 50 Oz camebak. I must say, though, I really like the bladder that comes with this pack: it is quick and easy to fill and never leaks. The rigid back plate that comes with some of the Osprey models is really not needed in something this small and close fitting to the body. The bite valve is not that great, but easy to replace. The picture shows the hydration bladder that comes with the pack.
This monitor will not give you that information. For more detail: http://www.suunto.com/m2fuchsia/
Yes, Garmin has done a good job with their apps for osx and ios.